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This inflammatory response may further activate TLR4 and JNK signaling, increase the release of pro-inflammatory cytokines, and exacerbate insulin resistance and metabolic dysregulation ( Retinol Metabolism and Transport: RBP4 binds retinol to form a complex that is stabilized in circulation by association with TTR, ensuring efficient delivery to target tissues ( CVDs-Related signaling: Elevated RBP4 levels are linked to CVDs including AS, CAD, and stroke ( Dysregulation of these RBP4-associated signaling pathways is closely implicated in the pathogenesis of various diseases, such as diabetes, AS, stroke, and CAD
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