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However, the average impact of PN and PN+ GSSG was a 27% decrease at 1 week, while at 16 weeks it was a 5% decrease

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That behavior is "particularly troublesome" for acetaminophen, an FDA report said, because the drug's narrow safety margin places "a large fraction of users close to a toxic dose in the ordinary course of use.” The FDA sets the maximum recommended daily dose of acetaminophen at 4 grams, or eight extra strength acetaminophen tablets