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The Biological Functions of Glutathione | Encyclopedia MDPI

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The α-subclass tumour necrosis factor, generated by myeloid and T-lineage cells following activation of NF-κB and MAPK modules, engages its cognate receptors to further propagate NF-κB-dependent transcription, initiate programmed cell death, and induce expression of vascular adhesion ligands (including ICAM-1 and VCAM-1), thereby facilitating immune cell tethering, arrest, and transendothelial passage