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The integration of whole-genome CRISPR/Cas9 knockout technology has revealed that the knockout of seven pivotal genes, FDX1, LIPT1, LIAS, DLD, DLAT, PDHA1 and PDHB, markedly mitigates the cytotoxic effects associated with copper ion carriers (5)

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Alternatively, the BBB can be temporarily bypassed by direct intracranial administration