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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Chapman AL, Skaff O, Senthilmohan R, Kettle AJ, Davies MJ
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Despite the encouraging antitumor activity, the development of PSMA ADC was discontinued due to off-target toxicity from premature deconjugation, leading to significant rates of ≥ grade 3 neurotoxicity (24%), neutropenia (8%) and three patients died of sepsis-related death (2.6%) 72,73,74
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