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As proof of concept that endosomal maturation inhibitors have clinical potential, CQ and hydroxy-CQ (HCQ), lysosomotropic agents that block endosomal acidification, are used to treat SLE 49 , RA 50 and, to a lesser extent, sJIA 51

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berghei lines Random-bred Swiss albino CD-1 female mice (Charles River Laboratories, Wilmington, MA, USA), 6–8 weeks old, weighing 20–35 g were used for the study