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51 Specifically, 9 miRNAs were upregulated ( hsa‐miR‐1‐3p , hsa‐miR‐31‐5p , hsa‐miR‐21‐3p , hsa‐miR‐150‐5p , hsa‐miR‐223‐3p , hsa‐miR‐21‐5p , hsa‐miR‐424‐3p , hsa‐miR‐326 and hsa‐miR‐342‐5p ), whereas 7 miRNAs were significantly downregulated in the lesional skin of severe PPR ( hsa‐miR‐144‐3p , hsa‐miR‐199b‐5p , hsa‐miR‐451a , hsa‐miR‐149‐5p , hsa‐miR‐1246 , hsa‐miR‐1290 and hsa‐miR‐196a‐5p ) compared to the non‐lesional skin
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Critical safety thresholds have been established for compounds like EGCG (800 mg/day limit) (240) and β-carotene (contraindicated in smokers), while hepatotoxicity cases linked to curcumin formulations have prompted regulatory warnings across multiple jurisdictions
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