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Buffering may protect more intact NAD+ from acid hydrolysis in the stomach, but research by Trammell and colleagues (2016) showed that oral NAD+ is largely broken down by intestinal enzymes before absorption in any case, suggesting buffering has a limited effect on total NAD+ metabolite delivery

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[DOI] [PubMed] [Google Scholar] 58.Berzoksky JA, Ahlers JD, Belyakov IM

It’s crucial to remember that results can vary based on individual skin concerns.