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Evaluations by imaging and nerve biopsy from RTD2 and RTD3 (mutations in SLC52A2 and SLC52A3 respectively [5,[103], [104], [105], [106]] individuals do show indications of axonal degeneration, neuronal loss [103,107], gliotic events, shortened axonal length [98,108] and variations in brain and spinal cord abnormalities [98,109]

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Efimova et al