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Additional Cys for GSH biosynthesis in astrocytes may also be obtained via the glutamate-cystine antiporter (X c − )-mediated uptake of extracellular cystine (CysCys) which is rapidly reduced to Cys within the intracellular compartment GSH efflux from astrocytes provides cysteine for neuronal GSH biosynthesis and the export of GSH conjugates from neurons and astrocytes is critical in the ultimate removal of conjugated cytotoxic xenobiotics
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