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Furthermore, GPS upregulates the expression of FXR and the Pregnane X Receptor (PXR), along with their downstream targets including the bile salt export pump (Bsep), multidrug resistance-associated protein 2 (Mrp2), multidrug resistance-associated protein 4 (Mrp4), organic solute transporter alpha/beta, and the metabolic enzyme Cytochrome P450 Family 3 Subfamily A Polypeptide 11 (CYP3A11)

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Common side effects: mild topical irritation or erythema, transient skin warmth at application site