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General Description Glutathione (GSH) is the most important nonprotein thiol widely distributed in animal tissues, plants, and microorganisms
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Indeed, several evidence demonstrated a protective effects of this natural compound in ototoxicity models (cisplatin or aminoglycoside-induced cochlear damage), showing how the ability of this molecule to inhibit apoptosis pathway, reduce mitochondrial ROS formation and potentiate the endogenous antioxidant system is the key molecular mechanisms of its therapeutic efficacy, both in vivo and in vitro models [53,54,91,92,93]
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