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93 Additionally, mTORC1 activity is suppressed during amino acid deprivation because RAP1 GTPases promote lysosome repositioning to the perinuclear region and reduce lysosomal abundance

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The demonstration of the association of genetics in the IL-23 pathway in multiple chronic inflammatory disorders, including inflammatory bowel disease (IBD), has coincided with significant advances in the understanding of its key role in host defense and organ-specific autoimmunity