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Cell Death Dis 2013;4:e626 [DOI] [PMC free article] [PubMed] [Google Scholar] 43.Ye D, Wang Y, Li H, Jia W, Man K, Lo CM, Wang Y, Lam KS, Xu A.Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1alpha-mediated antioxidant capacity in mice
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The study found that daily supplementation with at least 400 IU of synthetic vitamin E (equivalent to 180 mg of RRR -α-tocopherol) resulted in a 4% increase in risk of death from any cause compared to placebo (125)