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Finally, targeted manipulation of lipid-handling and immune-regulatory pathways, including SHIP1-dependent phosphoinositide remodeling and altered TREM signaling (335), regulation of the cholesterol transporter ABCA7 (313), and CRISPR-mediated targeting of immune checkpoint receptors (CD40, MERTK, CD47, SIRPα) to boost microglial phagocytic activity (328), further demonstrates the exceptional responsiveness of HMC3 cells to both pharmacological and genetic reprogramming
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Type:Blanche Classic Drip
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