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Other exclusion criteria were chronic renal, liver, neurological, pulmonary, or cardiovascular diseases, recent cigarette smoking within the previous 3 months, a history of substance abuse or addiction, the use of any medication within the previous month, and hypersensitivity to medications in the xanthine group such as theophylline or aminophylline

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The efficacy of ALCAR in protecting enzymes of the carnitine shuttle and myelin has not been addressed