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The anti-apoptotic protein Bcl-xL has been identified as a key regulator of this pathway, as it inhibits both MOMP in vivo and the formation of ceramide channels in vitro (Chang et al., 2015)

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Phase I human trial of parent molecule (TB-4) showed no serious adverse events Mild injection site reactions possible Same theoretical angiogenesis/tumor concern as BPC-157 Head rush or lightheadedness reported anecdotally at higher doses Can You Stack BPC-157 and TB-500