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relatively few studies measure direct transmission metrics (e.g., viral shedding rate, environmental persistence, R 0 in pond or experimental cohabitation models) in the same experiments that measure lethality, but the limited data show heterogeneous results, some deletion variants with lower per-host lethality shed comparable viral loads and sustain waterborne transmission in cohabitation assays (creating the theoretical possibility that lower lethality extends host infectious periods and thereby increases cumulative transmission), whereas other shrunken genomes produce lower viral titers and reduced secondary infection in sentinel animals, demonstrating that transmissibility is not rigidly predictable from genome size alone [80]
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