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Lactiplantibacillus plantarum C29 (often delivered as a fermented soybean preparation called DW2009) Evidence Randomized controlled trials in older adults with mild cognitive impairment showed: improved attention and memory scores increased brain-derived neurotrophic factor (BDNF) Proposed mechanism reduces gut inflammation increases BDNF (supports neuron survival and plasticity) improves gut barrier and reduces endotoxin signaling to the brain Strength of evidence: One of the strongest probiotic strains studied specifically for cognition in older adults 2
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