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The male Wistar rats were obtained from the Local Committee on Animal Research Ethics at Akdeniz University
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The story about GSH and apoptosis starts around the 1990s with the evidence of an active GSH extrusion from the cell undergoing apoptosis (van den Dobbelsteen et al., 1996) and with the subsequent conflicting notion that chemical depletion of GSH was not, however, sufficient to induce the apoptotic process ( c release into the cytosol, the starting condition for apoptotic intrinsic pathway commitment
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