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We examine here how these models have been improved with attention to physiological dimensions, geometry, and proximity to different cell types and simulation of blood flow past exposed endothelial cells (Figure 2)

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134,135 In caspase-1-dependent pyroptosis, the activation of inflammasome receptors such as NLRP1, NLRP3, NLRC4, AIM2 by PAMPs or DAMPs triggers the recruitment of the adapter proteins ASC and caspase-1 to form a macromolecular complex in which caspase-1 is activated