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AGE/RAGE action on vascular smooth muscle cells (VSMC) induces autophagy through the ERK/Akt pathway 454 and increases ROS and NOS levels through activation of NOX and NF-κB, 455,456 increases oxidative stress, and accelerates atherosclerotic plaque progression

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The promoter of the Ctt1 gene encoding cytoplasmic catalase T contains the characteristic STRE sequence regulated by transcription factor Mns2p and its close homologue Msn4p 75