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JAMA Psychiatry 78 , 261–269 (2021)

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Inclusions:Trial Set

An increase in behavioral reactivity in an open field following early postnatal Mn exposure (25–50 mg/kg/day orally) was associated with a reduction in evoked norepinephrine outflow, decrease in TH, DAT, NET, and D1 receptor protein levels in prefrontal cortex, in parallel with up-regulation of D2R protein levels and astrocyte reactivity assessed by GFAP (Conley et al., 2020)