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While the absorption rate for oral resveratrol is as high as 75%, almost all of that is broken down through first-pass digestion and never reaches any target tissues outside the evenly spread delivery from normal blood flow.2 And unlike certain drugs whose uptake can be improved by the presence of food — especially fatty foods — food intake appears to blunt the absorption of resveratrol.3 The most common approach to solving the resveratrol bioavailability conundrum has been to micronize it
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