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These two receptors are directly modulated by AMP-activated protein kinase (AMPK), an enzyme integral to lipid metabolism, which exerts its influence through phosphorylation mechanisms ( Mitogen-activated protein kinases (MAPKs) constitute a distinct family of serine-threonine protein kinases, which are activated by a variety of extracellular signals (Zhao et al., 2022a)
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The metabolomics data can confirm the role of oxidative stress and metabolic alterations in cellular processes, including redox homeostasis, energy balance, membrane integrity, and lipid metabolism by DON (Figure 1) (115)
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