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A potential future avenue includes long-acting analogues of LEAP2, a native antagonist of the ghrelin receptor, which may reduce food intake by attenuating ghrelin-mediated orexigenic and lipogenic signaling

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Since the increased amount of bilirubin is unconjugated, it is capable of penetrating the blood-brain barrier when its concentration in plasma exceeds that which can be tightly bound by albumin (20-25 mg/dL)