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Lipid oversupply may impair muscle insulin sensitivity via a multitude of mitochondria-dependent mechanisms, including (i) mitochondrial substrate competition ( 56 , 92 ), (ii) mitochondrial dysfunction–driven accumulation of intramuscular lipids ( 5 ), and (iii) excessive mitochondrial fatty acid oxidation ( 7 )

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doi: 10.1136/ard-2022-222501 [DOI] [PubMed] [Google Scholar] 167