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pc: placebo-controlled, db: double-blind, co: crossover design, RCT: randomized clinical trial, SBP: systolic blood pressure, DBP: diastolic blood pressure, CH: total cholesterol, LDL: low-density lipoprotein, ApoA1: apolipoprotein A1, PON: paraoxonase, HOMA-IR: homoeostasis model assessment-estimated insulin resistance, CRP: c-reactive protein, GSH: reduced glutathione, GSE: grape seed extract