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Here, spatiotemporal analyses carried out in both striatum and VM of young adult MPTP-injured mice (from 3 h to 49 days post lesion (dpt)) supported the early and profound nigrostriatal DAergic impairment and underscored a gradual and remarkable histopathological and functional DAergic recovery with time [49]

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However, when short peptides are administered alone, they can be presented by non-professional antigen-presenting cells (APCs) that lack the required costimulatory signals, potentially inducing T cell anergy or tolerance (Toes et al., 1996