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The symptoms began 2–19 days after starting ATRA.73 There are also reports of PTC in patients treated with the ATRA plus ATO combined regimen74 and rare reports of PTC secondary to ATO.75 The following signs and symptoms suggest a diagnosis of PTC: headache, blurred vision, diplopia, and nausea and vomiting with bilateral papilledema characterized by increased intracranial pressure and the presence of papilledema, normal or diminished ventricles and normal cerebrospinal fluid (CSF)