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Additional context-dependent phenotypes have been reported in neurodegeneration, including activated response microglia (ARMs), interferon-responsive microglia (IRMs) (77, 82–84), and human AD microglia (HAMs) (79), as well as in amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) (77, 85, 86), inflammatory disorders such as multiple sclerosis (MIMS) (87, 88), aging (lipid-droplet-accumulating microglia, LDAMs) (89, 90), and cancer (glioma-associated microglia, GAMs) (91, 92)