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High Vitamin B12 Levels May Be a Biomarker of Cancer A 2013 study published in the Journal of the National Cancer Institute reported that elevated serum cobalamin (vitamin B12) levels were associated with: 5 Subsequent cancer diagnoses, particularly within the first year of follow-up An increased risk of smoking-related, hematological (blood-related), and alcohol-related cancers Researchers concluded that elevated vitamin B12 levels may serve as a potential biomarker for cancer