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As mentioned prior, oxidation of carbon molecules in the mitochondria during cellular respiration is essential for generating energy for the cell in the form of ATP, but it also gives rise to reactive oxygen species
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However, the normal turnover of connective tissue matrices relies almost exclusively on the phagocytosis-mediated degradation of collagenous material by cathepsins, and much less by the functioning of MMP members, although it is generally accepted that all members can cleave ECM constituents [31,32]
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