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Consistent with anatomy and function, the partial O 2 pressure (pO 2 ) of atmospheric O 2 (~150–160 mmHg) drops in the lungs (60–150 mmHg), spleen (~16 mmHg demonstrated in rats) and thymus (10 mmHg) (Refs Reference Via53, Reference Aly57, Reference Brahimi-Horn and Pouyssegur135, Reference Braun136)

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The in-vivo evaluation can be performed to evaluate the present study