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Consistent with our present work, the level of 4-HNE and PTGS2 mRNA were observed to be remarkably elevated in seizure models ( FIGURE 3 Lapatinib Exerts Neuroprotection Against Glu- or Erastin-Induced Cell Death in HT22 Neurons To further explore the mechanism on how ferroptosis affects lapatinib’s neuroprotection against KA-induced epileptic seizures, we prepared a ferroptotic cell death model induced by Glu or erastin (a specific ferroptotic inducer)

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