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Conjugation of FA on graphene-based nanosystem can target and induce higher cytotoxicity on folate receptor- positive cells such as breast, ovarian, lung and colon cancers 54,55,56

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Specific antagonists include Dickkopf (Dkk), Wnt inhibitory factor 1 (WIF-1), [51] [52] secreted Frizzled-related proteins (SFRP), Cerberus, Frzb, Wise, SOST, and Naked cuticle