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its absence results in structurally unstable collagen which is not secreted from cells at a normal rate

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Additionally, there are no clear data about the effect of ascorbate on plasma anti-/pro-inflammatory cytokines, due to the fact that it is used in a mixture with other protective compounds, such as α-tocopherol, β-carotene, or 25-hydroxyvitamin D, which significantly downregulate pro-inflammatory molecules, such as interleukin 6 (IL-6) or interferon-γ (IFN-γ), and, to a different extent, influences the levels of anti-inflammatory interleukin 4 (IL-4) in human plasma [128,129]