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L'assimilation de la vitamine B 12 est compromise lorsque l'un des mécanismes ci-dessus fait défaut, par exemple lorsque l'estomac n'est plus assez acide (une partie de la population à partir de 50 ans), ou qu'il ne produit pas de facteur intrinsèque (anémie pernicieuse), et probablement pour certaines personnes traitées par IPP (inhibiteur de la pompe à protons)