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Parkinson's patients often experience muscle rigidity or cramping that can be painfulโmovements as simple as turning over in bed or buttoning a shirt can become arduous, and as the disease advances, nearly impossible
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Variants:Bloom B2G1 (3pcs)
Additionally, end joining is well documented following fork collapse at a trapped TOP1 complex 28,50,51,52 , where TOP1 negatively regulates collapse of single forks and favors synchronous collapse of converging forks 43
