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High homocysteine links to many diseases and can affect: Glutathione production (your body's master antioxidant) Hormonal balance maintenance Mitochondrial protection Energy production capacity Anyone with methylation challenges should talk to a healthcare expert who understands methylation biochemistry before trying NAD+ supplements

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These co-morbidities further increase the burden of this disease, and affect the QoL [10,11,12 ▪▪ ]