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Furthermore, after tests on AML12 cells (normal mouse hepatocytes), it was found that compounds 8 and 9 did not show significant cytotoxicity, while compound 7 showed little cytotoxicity
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The 4-HNE adducts accumulate in the lipid necrotic core of advanced atherosclerotic lesions and may locally participate in macrophage and smooth muscle cell apoptosis, resulting in plaque instability and rupture, thus increasing the risk of atherosclerotic thrombosis events [116]
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