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Now after phoning today, I’m told one doctor is looking at everyone who receives a B12 injection is being referred to one doctor for blood tests to see if we still need it." Similarly, another wrote: "I had to fight with GP to continue [injections], at present awaiting blood results to see if injection [sic] will be stopped or continues." Some participants even said they were not offered an alternative, while others reported experiencing increased fatigue, a fuzzy brain, forgetfulness and more as a result of the change from injections to tablets

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Hedgehog signaling pathway was shown to be involved in activation of stem cells after Tβ4 treatment, which may contribute to therapeutic benefit (Kim et al., 2017)