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12.3 Pharmacokinetics Following intravenous administration of hydroxocobalamin significant binding to plasma proteins and low molecular weight physiological compounds occurs, forming various cobalamin-(III) complexes by replacing the hydroxo ligand

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[253] reported changes in 30 microbial markers after quetiapine treatment, and 10 of them presented an area under the curve (AUC) of 0.93 between responder and no responder patients, denoting a potential application of gut microbiota as a predictive biomarker