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The cGAS-STING pathway is a major cytosolic DNA-sensing pathway, where cGAS detects foreign DNA and synthesizes cyclic GMP-AMP, which then binds to and activates STING

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These two pathways cooperate in several ways: IFN-I generated by cGAS-STING heightens NLRP3 sensitivity, and NLRP3-dependent IL-1β upregulates cGAS via NF-KB, creating a positive-feedback loop