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Various neurotransmitters, including acetylcholine (ACh), dopamine, opioids, serotonin, somatostatin, adenosine, and γ-aminobutyric acid (GABA), stimulate their respective G protein-coupled receptors (GPCRs) (Luscher and Slesinger, 2010) which couple to pertussis toxin (PTX)-sensitive heterotrimeric G proteins (G i/o ) (Figure 1)

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