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Diagnosis and differential diagnosis Diagnosis In HCC patients receiving molecular targeted therapy for more than one week or ICIs for four to twelve weeks, a diagnosis of DILI can be established if two or more of the following criteria are met: (1) Presence of symptoms such as fever, fatigue, nausea, or generalized discomfort, accompanied by abnormal liver biochemical markers (including ALT, AST, ALP, GGT, TBIL, albumin, etc.)