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Some studies have suggested that excluding participants who had gastroenteritis prior to the first use of PPIs or correcting for confounding factors, such as susceptibility and time dependence of bacterial gastrointestinal infections, can remarkably reduce the association between PPI treatment and bacterial gastroenteritis ( Diseases caused by fungal infections of the digestive system have also been linked to the use of PPIs, particularly Candida infections (Mottaghi et al., 2021)