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Neoplastic fibroses emerge directly from the hyperproliferation of fibroblasts or their mesenchymal progenitors [dermatofibrosarcoma protuberans (DFSP), desmoid tumor, fibrous hamartoma of infancy, infantile myofibromatosis, sarcomas, and other fibrohistiocytic neoplasms] or indirectly from the transforming effects of oncogenes in the dermis (sclerotic fibroma from phosphatase and tensin homolog mutations in Cowden syndrome and connective tissue nevi from AKT serine/threonine kinase 1 mutations in Proteus syndrome)

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Storage of neural histamine and histaminergic neurotransmission is VMAT2 dependent in the zebrafish