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Places of Service for CPT Code 20220 The most common POS codes for CPT 20220 include: 22 – Hospital outpatient 24 – Ambulatory surgical center 11 – Physician office (when performed in-office with proper equipment) 21 – Hospital inpatient for medically complex or infectious scenarios 23 – Emergency department (less common but possible)  The POS must reflect where the biopsy occurred—not where the patient was evaluated