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Vitamin E also prevents the metabolism of 12-LOX, a key mediator of glutamate-induced neurodegeneration, by preventing arachidonic acid from entering the catalytic site of 12-LOX and enabling vitamin E to effectively prevent neuronal degeneration ( Carotenoids are widely present in plant pigments, and their chemical structure is a polymer of 8 isoprene and an oxidized derivative thereof, which is a precursor of vitamin A
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